Anglican worship started in the Church of England schoolhouse on the corner of Victoria Parade and Hoddle Street in 1857 – serving as a mission church to the working class families on the low-lying Richmond and Collingwood flats.

In 1863 a bluestone church was built on the George Street corner of the present site – a place designated as the site for the Cathedral. That church was destroyed by fire in 1905 and the present church was built at the opposite end of the block and consecrated in October 1907.

In 1970 the former Vicarage on Clarendon Street was sold and the present house was purchased. From 2004 the parish hall was the temporary home for the East Melbourne Library whilst its new building was being constructed on George Street. From August 2006 it is the administrative offices for AngliCORD.